First came Ozempic face, then Ozempic butt and even Ozempic feet—but now a new side effect of the wildly popular weight-loss drug is raising eyebrows among doctors and fans alike: Ozempic mouth.
According to top New York-based cosmetic dermatologist Dr. Michele Green, “Ozempic mouth” is becoming increasingly common among people using GLP-1 drugs like Ozempic, Wegovy, and Zepbound. And the aesthetic toll it takes on the face—especially the lips and chin—can be both dramatic and aging.
What Is ‘Ozempic Mouth’?
Dr. Green describes the condition as a distinct loss of volume around the mouth, characterized by:
- Deep folds at the corners of the lips
- Vertical lip lines or “lipstick lines”
- Sagging around the mouth and jaw
- Drooping chin skin (jowls)
These effects, she says, stem from rapid fat loss, especially in those using high doses of the drug.
“Ozempic works by decreasing appetite and promoting weight loss—but that includes fat loss in the face,” Dr. Green told DailyMail.com. “When you lose the subcutaneous fat around your mouth, everything begins to sag and wrinkle. It contributes to a prematurely aged appearance.”
Celebrities Showing the Signs
Dr. Green and other experts point to several high-profile stars who appear to be experiencing the effects of Ozempic mouth.
- Sharon Osbourne, who admitted to losing “too much weight” on the drug, is now showing sagging skin around her lips and lower face.
- Rebel Wilson, who shed more than 70 pounds, is said to show visible sagging around her chin and smile.
- Whoopi Goldberg is another celebrity named by Dr. Green, citing deep lines and jowl formation as signs of Ozempic’s impact.
Even Harvey Fierstein, who lost 120 lbs with help from Zepbound (another GLP-1 drug), has reportedly developed sagging facial features.
Meanwhile, social media has been flooded with speculation about Katy Perry, Scott Disick, Jessica Simpson, and others who are showing gaunt, drawn appearances—all potentially linked to rapid weight loss from these medications.
Why It Happens
Dr. Barry Weintraub, a board-certified plastic surgeon in New York, explains: “Ozempic depletes subcutaneous fat, the pinchable layer just under your skin. When that disappears, the skin has nothing to hold it up—and it sags.”
He adds that this can also affect water retention, leading to dryness and an increased appearance of fine lines, especially around the mouth.
The issue, experts say, isn’t just about weight loss—but how quickly that weight is lost.
“The faster you lose fat, the less time your skin has to adapt,” says Dr. Green. “That’s why we’re seeing so many patients come in asking for help.”
The Fix: Fillers and Thermage—But at a Cost
To combat Ozempic mouth, many patients are turning to dermal fillers—gel-like substances injected under the skin to restore volume and reduce sagging.
“Fillers can rejuvenate the area around the mouth, smooth out wrinkles, and bring back a more youthful appearance,” Dr. Green explains. But with an average cost of $700 to $2,000 per syringe, and some patients needing multiple syringes, it’s not a cheap solution.
Another non-invasive fix? Thermage, a radiofrequency skin-tightening procedure that stimulates collagen production.
“Thermage can firm and lift sagging skin,” Green says, “but the results take four to six months to appear and typically cost between $1,500 and $3,500.”
For those considering starting Ozempic or similar drugs, Dr. Green advises beginning Thermage treatments early to prevent facial sagging, rather than trying to reverse it later.
Aesthetic Trade-Offs of Rapid Weight Loss
The explosion of Ozempic and similar drugs has reshaped not just waistlines but also faces, feet, butts, and smiles. Among the more bizarre effects:
- Ozempic feet – Extreme sagging in the feet due to fat loss, making shoes painful and bones prominent
- Ozempic butt – Flattened or “deflated” buttocks, leaving some users embarrassed and self-conscious
A 2024 survey found that 1 in 8 Americans has taken a GLP-1 drug—many of them off-label for weight loss. But as more users share side effect stories, experts are urging caution and realistic expectations.
What You Can Do
Dr. Ilana Ramer Bass of Mount Sinai Health System advises patients to slow down their weight loss journey to preserve facial structure.
“Talk to your doctor about adjusting your dosage for a more gradual approach,” she says. “Eat small, well-balanced meals rich in fiber and protein to keep your skin hydrated and healthy.”
She adds: “If you’re concerned about aging effects, consult a dermatologist before turning to surgery. Prevention and early care are key.”
As Ozempic continues to rise in popularity, Ozempic mouth serves as the latest reminder that in the pursuit of slim, youthful bodies, our faces — and smiles — may pay the hidden price.